US 7,459,502 B2
	Pharmaceutical compositions comprising crosslinked polyamine polymers
Eric Connor, Los Gatos, Calif. (US); Dominique Charmot, Campbell, Calif. (US); Han Ting Chang, Livermore, Calif. (US); Florence Roger, Santa Clara, Calif. (US); Gerrit Klearner, San Jose, Calif. (US); and Son Hoai Nguyen, San Jose, Calif. (US)
Assigned to Ilypsa, Inc., Thousand Oaks, Calif. (US)
Filed on Oct. 13, 2004, as Appl. No. 10/965,044.
Application 10/965044 is a continuation in part of application No. 10/806495, filed on Mar. 22, 2004, granted, now 7,335,795.
Application 10/806495 is a continuation in part of application No. 10/701385, filed on Nov. 03, 2003, granted, now 7,385,012.
Prior Publication US 2005/0131138 A1, Jun. 16, 2005
This patent is subject to a terminal disclaimer.
Int. Cl. C08F 26/06 (2006.01)

U.S. Cl. 525—374  [526/310; 526/258; 424/78.12; 521/36; 524/612]

34 Claims

1. A pharmaceutical composition comprising a phosphate binding crosslinked amine polymer as an active ingredient and a pharmaceutically acceptable excipient, the crosslinked amine polymer comprising a polyamine polymer derived from the polymerization of an amine monomer, the polyamine polymer being crosslinked with a crosslinking agent, wherein the crosslinked amine polymer has a gel pore volume and less than about 20% of the gel pore volume is accessible to non-interacting solutes of molecular weight greater than about 200 as measured in a physiological medium which is isotonic and neutral pH.