wherein

A is substituted or unsubstituted pyridinyl or substituted or unsubstituted pyrazinyl, wherein the pyridinyl and pyrazinyl are substituted with from 1-4 R¹ substituents;

B is

wherein

R^7A is independently H, —OH, —NH₂, —NO₂, —SO₂NH₂, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl, substituted or unsubstituted 5- to 7- membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

R^7B is independently H or substituted or unsubstituted alkyk; and

y is an integer from 1 to 4, wherein two R^7A groups are optionally joined together with the atoms to which they are attached to form a substituted or unsubstituted 5- to 7- membered cycloalkyl, substituted or unsubstituted 5- to 7-membered heterocycloalkyl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted aryl;

X is a bond or —NR⁴—;

k is an integer from 1 to 3;

R¹ and R² are independently H, —OH, —NH₂, —NO₂, —SO₂NH_2, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl, substituted or unsubstituted 5- to 7- membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;

R⁴ is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted 3- to 7- membered cycloalkyl, substituted or unsubstituted 5- to 7- membered heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and

wherein

the substituents for alkyl and heteroalkyl are selected from the group consisting of —OR′, ═O, ═NR′, ═N—OR′, —NR′R″, —SR′, -halogen, —SiR′R″R′″, —OC(O)R′, —C(O)R′, —CO₂R′, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R′, —NR′—C(O)NR″R′″, —NR″C(O)₂R′, —NR—C(NR′R″R′″)═NR″″, —NR—C(NR′R″)═NR′″, —S(O)R′, —S(O)₂R′, —S(O)₂NR′R″, —NRSO₂R′, —CN and —NO₂ in a number ranging from zero to (2m′+1), where m′ is the total number of carbon atoms in such radical, wherein R′, R″, R′″ and R″″ are each independently refer to hydrogen, unsubstituted heteroalkyl, unsubstituted aryl, unsubstituted alkyl, alkoxy or thioalkoxy groups, or arylalkyl groups; and

the substituents for aryl and heteroaryl are selected from the group consisting of halogen, —OR′, —NR′R″, —SR, -halogen, —SiR′R″R′″, —OC(O)R′, —C(O)R′, -CO₂R′, —CONR′R″, —OC(O)NR′R″, —NR′C(O)R′, —NR′—C(O)NR′R″, —NR′C(O)₂R′, —NR′—C(NR′R″R′″)═NR^W, —NR′—C(NR′R″)═NR′″, —S(O)R′, —S(O)₂R′, —S(O)₂NR′R″, —NRSO₂R′, —CN and —NO₂, —R′, —N₃, —CH(Ph)₂, fluoro(C₁-C₄)alkoxY, and fluoro(C₁-C₄)alkyl, in a number ranging from zero to the total number of open valences on the aromatic ring system; and where R′,R″,R′″ and R^W are independently selected from hydrogen, alkyl, heteroalkyl, aryl and heteroaryl,

wherein if k is greater than one, then each R² is optionally different.