US 7,459,432 B2
Modification of feeding behavior
Michael Cowley, Portland, Oreg. (US); Roger Cone, Oregon City, Oreg. (US); Malcolm Low, Lake Oswego, Oreg. (US); Andrew Butler, Baton Rouge, La. (US); Stephen Robert Bloom, London (United Kingdom); Caroline Jane Small, London (United Kingdom); Rachel Louise Batterham, London (United Kingdom); and Mohammad Ali Ghatel, London (United Kingdom)
Assigned to Imperial College Innovations Ltd., London (United Kingdom); and Oregon Health and Science University, Portland, Oreg. (US)
Appl. No. 10/490,776
PCT Filed Sep. 24, 2002, PCT No. PCT/US02/31944
§ 371(c)(1), (2), (4) Date Mar. 24, 2004,
PCT Pub. No. WO03/026591, PCT Pub. Date Apr. 03, 2003.
Claims priority of provisional application 60/324406, filed on Sep. 24, 2001.
Claims priority of provisional application 60/392109, filed on Jun. 28, 2002.
Claims priority of application No. 0200507.2 (GB), filed on Jan. 10, 2002.
Prior Publication US 2005/0176630 A1, Aug. 11, 2005
Int. Cl. A61K 38/22 (2006.01); C07K 14/575 (2006.01)
U.S. Cl. 514—12  [530/303; 530/324] 18 Claims
OG exemplary drawing
 
1. A method for decreasing calorie intake, food intake or appetite, in a human subject in need thereof, comprising peripherally administering prior to a meal to said subject PYY3-36 (SEQ ID NO:334) in a dose of from 5 to 100 nmoles per 70 to 75 kg body weight of said subject.