US 7,459,171 B2
	Method for the improvement of transport across adaptable semi-permeable barriers
Gregor Cevc, Gauting (Germany); Holger Richardsen, München (Germany); and Andrea Weiland-Waibel, Hohenbrunn (Germany)
Assigned to Idea AG, Munich (Germany)
Filed on Jan. 04, 2002, as Appl. No. 10/37,480.
Prior Publication US 2003/0099694 A1, May 29, 2003
Int. Cl. A61K 13/00 (2006.01); A61K 9/70 (2006.01); A61K 9/127 (2006.01); B01D 61/00 (2006.01); B01D 63/00 (2006.01)

U.S. Cl. 424—449  [424/443; 424/448; 424/450; 210/645; 210/321.75]

9 Claims

1. A patch comprising: a non-occlusive backing liner and an inner liner, wherein the backing liner and the inner liner define a reservoir, wherein the non-occlusive backing liner exhibits a mean vapor transmission rate (MVTR) of more than 1000 g/m2day, the patch containing a formulation prepared by suspending or dispersing penetrants in a polar liquid in the form of fluid droplets surrounded by a membrane-like coating of one or several layers, said coating comprising at least two kinds or forms of amphiphilic substances with a tendency to aggregate, wherein said at least two substances differ by at least a factor of 10 in solubility in said polar liquid, wherein said penetrants are able to transport agents through the pores of an adaptable semi-permeable porous barrier or enable agent permeation through the pores of said barrier after penetrants have entered the pores, wherein the barrier is skin or mucosa of a mammalian body or cuticle of a plant, the pH of the formulation is between 3 and 10, and wherein the formulation is present in an amount corresponding to a desired dose per area.