	US 7,449,595 B2
	Nitrosated and nitrosylated prostaglandins, compositions and methods of use
David S. Garvey, Dover, Mass. (US); Ricky D. Gaston, Malden, Mass. (US); L. Gordon Letts, Dover, Mass. (US); Inigo Saenz de Tejada, Madrid (Spain); Sang William Tam, Dover, Mass. (US); and Manuel Worcel, Boston, Mass. (US)
Assigned to NitroMed, Inc., Lexington, Mass. (US)
Filed on Dec. 19, 2006, as Appl. No. 11/641,050.
Application 11/641050 is a division of application No. 09/516194, filed on Mar. 01, 2000, granted, now 7,176,238.
Claims priority of provisional application 60/138502, filed on Jun. 09, 1999.
Claims priority of provisional application 60/122273, filed on Mar. 01, 1999.
Prior Publication US 2007/0112067 A1, May 17, 2007
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 405/00 (2006.01); A61K 31/557 (2006.01)

U.S. Cl. 560—121

9 Claims

1. A compound selected from the group consisting of:

(2S,3S)-2,3,4-tris(nitroxy)butyl 7-[5-((1E)(3S)-3-hydroxyoct-1-enyl)(1R,4R,5R)-4-hydroxy-2-oxocyclopentyl]heptanoate;

(2S)-2,3-bis(nitroxy)propyl 7-[5-((1E)(3S)-3-(nitrooxyoct-1-enyl)(1R,4R,5R)-4-(nitrooxy)-2-oxocyclopentyl]heptanoate;

3-nitrooxy-2,2-bis(nitrooxymethyl)propyl 7-[5-((1E)(3S)-3-hydroxyoct-1-enyl)(1R,4R,5R)-4-hydroxy-2-oxocyclopentyl]heptanoate;

3-nitrooxy-2,2-bis[(nitrooxy)methyl]propyl 7-[5-[(1E)(3S)-3-(nitrooxyoct-1-enyl)(1R,4R,5R)-4-nitrooxy-2-oxocyclopentyl]heptanoate;

methyl 7-[5-((1E)(3S)-3-nitroxyoct-1-enyl)(1R,4R,5R)-4-nitrooxy-2-oxocyclopentyl]heptanoate;

2-[2-(nitrosothio)adamantan-2-yl]ethyl 7-[5-((1E)(3S)-3-hydroxyoct-1-enyl)(1R,4R,5R)-4-hydroxy-2-oxocyclopentyl]heptanoate;

[{1-[(4-methylphenyl)sulfonyl]-4-(nitrosothiol)-4-piperidyl}methyl 7-[5-((1E)(3S)-3-hydroxyoct-1-enyl)(1R,4R,5R)-4-hydroxy-2-oxocyclopentyl]heptanoate; and

2-methyl-2-(nitrosothio)propyl 7-[5-((1E)(3S)-3-hydroxyoct-1-enyl)(1R,4R,5R)-4-hydroxy-2-oxocyclopentyl]heptanoate; or a pharmaceutically acceptable salt thereof.