a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein

ring A is phenyl;

R¹ represents hydrogen; aryl; formyl; C_1-6alkylcarbonyl; C_1-6alkyl; C_1-6alkyloxycarbonyl; C_1-6alkyl substituted with formyl, C_1-6alkylcarbonyl, C_1-6alkyloxycarbonyl, C_1-6alkylcarbonyloxy; or C_1-6alkyloxyC_1-6alkylcarbonyl optionally substituted with C_1-6alkyloxycarbonyl;

X₁ represents a direct bond; —(CH₂)_n3— or —(CH₂)_n4—X_1a—X_1b—;

with n₃ representing an integer with value 1, 2, 3 or 4;

with n₄ representing an integer with value 1 or 2;

with X_1a representing O, C(═O) or NR⁵; and

with X_1b representing a direct bond or C_1-2alkyl;

R² represents C_3-7cycloalkyl; phenyl; a 4, 5, 6- or 7-membered monocyclic heterocycle containing at least one heteroatom selected from O, S or N; benzoxazolyl or a radical of formula

wherein —B—C— represents a bivalent radical of formula

—CH₂—CH₂—CH₂—  (b-1);

—CH₂—CH₂—CH₂—CH₂—  (b-2);

—X₃—CH₂—CH₂—(CH₂)_n—  (b-3);

—X₃—CH₂—(CH₂)_n—X₃—  (b-4);

—X₃—(CH₂)_n′—CH═CH—  (b-5);

—CH═N—X₃—  (b-6);

with X₃ representing O or NR⁵;

n representing an integer with value 0, 1, 2 or 3;

n′ representing an integer with value 0 or 1;

wherein said R substituent, where possible, may optionally be substituted with at least one substituent selected from halo; hydroxy; C_1-6alkyl optionally substituted with at least one substituent selected from hydroxy, cyano, carboxyl, C_1-4alkyloxy, C_1-4alkyloxyC_1-4alkyloxy, C_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyloxy, NR⁶R⁷, —C(═O)—NR⁶R⁷, —NR⁵—C(═O)—NR⁶R⁷, —S(═O)_n1—R⁸ or —NR⁵—S(═O)_n1—R⁸; C_2-6alkenyl or C_2-6alkynyl, each optionally substituted with at least one substituent selected from hydroxy, cyano, carboxyl, C_1-4alkyloxy, C_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyloxy, NR⁶R⁷, —C(═O)—NR⁶R⁷, —NR⁵—C(═O)—NR⁶R⁷, —S(═O)_n1—R⁸ or —NR⁵—S(═O)_n1—R⁸; polyhalo-C_1-6alkyl optionally substituted with at least one substituent selected from hydroxy, cyano, carboxyl, C_1-4alkyloxy, C_1-4alkyloxyC_1-4alkyloxy, C_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyloxy, NR⁶R⁷, —C(═O)—NR⁶R⁷, —NR⁵—C(═O)-NR⁶R⁷, —S(═O)_n1—R⁸ or —NR⁵—S(═O)_n1—R⁸; C_1-6alkyloxy optionally substituted with at least one substituent selected from hydroxy, cyano, carboxyl, C_1-4alkyloxy, C_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyloxy, NR⁶R⁷, —C(═O)—NR⁶R⁷, —NR⁵—C(═O)—NR⁶R⁷, —S(═O)_n1—R⁸ or —NR⁵—S(═O)_n1—R⁸; polyhaloC_1-6alkyloxy optionally substituted with at least one substituent selected from hydroxy, cyano, carboxyl, C_1-4alkyloxy, C_1-4alkyloxyC_1-4alkyloxy, C_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyloxy, NR⁶R⁷, —C(═O)—NR⁶R⁷, —NR⁵—C(═O)—NR⁶R⁷, —S(═O)_n1—R⁸ or —NR⁵—S(═O)_n1—R⁸; C_1-6alkylthio; polyhaloC_1-6alkylthio; C_1-6alkyloxycarbonyl; C_1-6alkylcarbonyloxy; C_1-6alkylcarbonyl; polyhaloC_1-6alkylcarbonyl; cyano; carboxyl; aryloxy; arylthio; arylcarbonyl; arylC_1-4alkyl; arylC_1-4alkyloxy; NR⁶R⁷; C(═O)NR⁶R⁷; —NR⁵—C(═O)—NR⁶R⁷; —NR⁵—C(═O)—R⁵; —S(═O)_n1—R⁸; —NR⁵—S(═O)_n1—R⁸; —S—CN; —NR⁵—CN; oxazolyl optionally substituted with C_1-4alkyl; imidazolyl optionally substituted with C_1-4alkyl; or

with n2 representing an integer with value 0, 1, 2, 3 or 4;

with X₄ representing O, NR⁵ or a direct bond;

with X₅ representing O, CH₂, CHOH, CH—N(R₅)₂, NR⁵ or N—C(═O)—C_1-4alkyl;

X₂ represents a direct bond; —NR¹—; —NR¹—(CH₂)_n3—; —O—; —O—(CH₂)_n3—; —C(═O)—; —C(═O)—(CH₂)_n3—; —C(═O)—NR⁵—(CH₂)_n3—; —C(═S)—; —S—; —S(═O)_n1—; —(CH₂)_n3—; —(CH₂)_n4—X_1a—X_1b—; —X_1a—X_1b—(CH₂)_n4—; —S(═O)_n1—NR⁵—(CH₂)_n3—NR⁵—; or —S(═O)_n1—NR⁵—(CH₂)_n3—;

R³ represents a 5- or 6-membered monocyclic heterocycle containing at least one heteroatom selected from O, S or N, or a 9- or 10-membered bicyclic heterocycle containing at least one heteroatom selected from O, S or N, wherein said R³ substituent, where possible, may optionally be substituted with at least one substituent selected from halo; hydroxy; C_1-6alkyl optionally substituted with at least one substituent selected from hydroxy, cyano, carboxyl, C_1-4alkyloxy, C_1-4alkyloxyC_1-4alkyloxy, C_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyloxy, NR⁶R⁷, —C(═O)—NR⁶R⁷, —NR⁵—C(═O)—NR⁶R⁷, —S(═O)_n1—R⁸ or —NR⁵—S(═O)_n1—R⁸; C_2-6alkenyl or C_2-6alkynyl, each optionally substituted with at least one substituent selected from hydroxy, cyano, carboxyl, C_1-4alkyloxy, C_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyloxy, NR⁶R⁷, —C(═O)—NR⁶R⁷, —NR⁵—C(═O)—NR⁶R⁷, —S(═O)_n1—R⁸ or —NR⁵—S(═O)_n1—R⁸; polyhaloC_1-6alkyl; C_1-6alkyloxy optionally substituted with at least one substituent selected from hydroxy, cyano, carboxyl, C_1-4alkyloxy, C_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyloxy, NR⁶R⁷, —C(═O)—NR⁶R⁷, —NR⁵—C(═O)—NR⁶R⁷, —S(═O)_n1—R⁸ or —NR⁵—S(═O)_n1—R⁸; polyhaloC_1-6alkyloxy; C_1-6alkylthio; polyhaloC_1-6alkylthio; C_1-6alkyloxycarbonyl; C_1-6alkylcarbonyloxy; C_1-6alkylcarbonyl; polyhaloC_1-6alkylcarbonyl; cyano; carboxyl; NR⁶R⁷; C(═O)NR⁶R⁷; —NR⁵—C(═O)—NR⁶R⁷; —NR⁵—C(═O)—R⁵; —S(═O)_n1—R⁸; —NR⁵—S(═O)_n1—R⁸; —S—CN; —NR⁵—CN; or

 and in case R³ represents a saturated or a partially saturated 5- or 6-membered monocyclic heterocycle containing at least one heteroatom selected from O, S or N, said R³ may also be substituted with at least one oxo;

R⁴ represents hydrogen; halo; hydroxy; C_1-4alkyl optionally substituted with at least one substituent selected from hydroxy, cyano, carboxyl, C_1-4alkyloxy, C_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyloxy, NR⁹R¹⁰, —C(═O)—NR⁹R¹⁰, —NR⁵—C(═O)—NR⁹R¹⁰, —S(═O)_n1—R¹¹ or —NR⁵—S(═O)_n1—R¹¹; C_2-4alkenyl or C_2-4alkynyl, each optionally substituted with at least one substituent selected from hydroxy, cyano, carboxyl, C_1-4alkyloxy, C_1-4alkylcarbonyl, C_1-4alkyloxycarbonyl, C_1-4alkylcarbonyloxy, NR⁹R¹⁰, —C(═O)—NR⁹R¹⁰, —NR⁵—C(═O)—NR⁹R¹⁰, —S(═O)_n1—R¹¹ or —NR⁵—S(═O)_n1—R¹¹; polyhaloC_1-3alkyl; C_1-4alkyloxy optionally substituted with carboxyl; polyhaloC_1-3alkyloxy; C_1-4alkylthio; polyhaloC_1-3alkylthio; C_1-4alkyloxycarbonyl; C_1-4alkylcarbonyloxy; C_1-4alkylcarbonyl; polyhaloC_1-4alkylcarbonyl; nitro; cyano; carboxyl; NR⁹R¹⁰; C(═O)NR⁹R¹⁰; —NR⁵—C(═O)—NR⁹R¹⁰; —NR⁵—C(═O)—R⁵; —S(═O)_n1—R¹¹; —NR⁵—S(═O)_n1—R¹¹; —S—CN; or —NR⁵—CN;

R⁵ represents hydrogen, C_1-4alkyl or C_2-4alkenyl;

R⁶ and R⁷ each independently represent hydrogen; cyano; C_1-6alkylcarbonyl optionally substituted with C_1-4alkyloxy or carboxyl; C_1-6alkyloxycarbonyl; C_3-7cycloalkylcarbonyl; adamantanylcarbonyl; C_1-4alkyloxyC_1-4alkyl; C_1-4alkyl substituted with C_1-4alkyl-NR⁵—; C_1-6alkyl optionally substituted with at least one substituent selected from halo, hydroxy, cyano, carboxyl, C_1-4alkyloxy, polyhaloC_1-4alkyl, C_1-4alkyloxyC_1-4alkyloxy, NR^6aR^7a, C(═O)NR^6aR^7a or

 with X₆ representing O, CH₂, CHOH, CH—N(R₅)₂, NR⁵ or N—C(═O)—C_1-4alkyl;

R^6a and R^7a each independently represent hydrogen; C_1-4alkyl or C_1-4alkylcarbonyl;

R⁸ represents C_1-4alkyl optionally substituted with hydroxy; polyhaloC_1-4alkyl or NR⁶R⁷;

R⁹ and R¹⁰ each independently represent hydrogen; C_1-6alkyl; cyano; C_1-6alkylcarbonyl; C_1-4alkyloxyC_1-4alkyl; or C_1-4alkyl substituted with C_1-4alkyl-NR⁵—;

R¹¹ represents C_1-4alkyl or NR⁹R¹⁰;

n1 represents an integer with value 1 or 2;

aryl represents phenyl or phenyl substituted with at least one substituent selected from halo, C_1-6alkyl, C_3-7cycloalkyl, C_1-6alkyloxy, cyano, nitro, polyhaloC_1-6alkyl or polyhaloC_1-6alkyloxy.