US 7,605,248 B2
Recombinant constructs of Borrelia burgdorferi
Raymond J. Dattwyler, Setauket, N.Y. (US); Maria J. C. Gomes-Solecki, New York, N.Y. (US); Benjamin J. Luft, East Setauket, N.Y. (US); and John J. Dunn, Bellport, N.Y. (US)
Assigned to Research Foundation of the State University of New York, Stony Brook, N.Y. (US); and Brookhaven Sciences Associates, LLC, Upton, N.Y. (US)
Filed on Sep. 26, 2006, as Appl. No. 11/527,161.
Application 11/527161 is a division of application No. 11/196475, filed on Aug. 03, 2005, granted, now 7,179,448.
Application 11/196475 is a division of application No. 10/369100, filed on Feb. 18, 2003, granted, now 7,008,625.
Application 10/369100 is a continuation of application No. PCT/US01/24736, filed on Aug. 07, 2001.
Application PCT/US01/24736 is a continuation in part of application No. 09/666017, filed on Sep. 19, 2000, abandoned.
Application 09/666017 is a continuation in part of application No. 08/235836, filed on Apr. 29, 1994, granted, now 6,248,562.
Application 08/235836 is a continuation in part of application No. 08/148191, filed on Nov. 01, 1993, abandoned.
Claims priority of provisional application 60/226484, filed on Aug. 18, 2000.
Prior Publication US 2007/0020286 A1, Jan. 25, 2007
Int. Cl. C07H 21/04 (2006.01); C07H 21/02 (2006.01); A61K 39/02 (2006.01)
U.S. Cl. 536—23.7  [536/23.1; 530/300; 530/350; 424/9.1; 424/9.2; 424/243.1] 12 Claims
 
1. A nucleic acid encoding a protein comprising at least a first and a second polypeptide, wherein the first polypeptide comprises OspC from Borrelia burgdorferi sensu lato and wherein the second polypeptide comprises OspA from Borrelia burgdorferi sensu lato, such that the first polypeptide is linked to the N-terminus of the second polypeptide.