| US 7,605,242 B2 | ||
| Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom | ||
| Luigi De Ambrosi, Santhià (Italy); Donata Bensi, Vercelli (Italy); and Elena Vismara, Milan (Italy) | ||
| Assigned to Laboratori Derivati Organici S.p.A., Vercelli (VC) (Italy) | ||
| Appl. No. 10/555,897 PCT Filed May 06, 2004, PCT No. PCT/EP2004/050723 § 371(c)(1), (2), (4) Date Apr. 18, 2006, PCT Pub. No. WO2004/099256, PCT Pub. Date Nov. 18, 2004. |
||
| Claims priority of application No. 03076388 (EP), filed on May 09, 2003. | ||
| Prior Publication US 2006/0237302 A1, Oct. 26, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. C08B 37/00 (2006.01); C08B 37/10 (2006.01) | ||
| U.S. Cl. 536—21 [536/53; 536/54; 204/157.68] | 7 Claims |
| 1. A dynamic irradiation process for the depolymerization of heparin wherein the depolymerized heparin has a Mw less than or equal to 50% of the original Mw of said heparin prior to depolymerization, said dynamic irradiation process comprising exposing said heparin in solution at a concentration between 2 and 25% w/v to UV radiation having a peak of from 245 nm to 260 nm for a sufficient time to reduce the Mw of the depolymerized heparin by at least 50% as compared with the Mw of said heparin prior to said exposure to UV radiation. |