US 7,604,820 B1
	Solid preparation containing chitosan powder and process for producing the same
Norihito Shimono, Kobe (Japan); Masaaki Mori, Otsu (Japan); and Yutaka Higashi, Osaka (Japan)
Assigned to Dainippon Sumitomo Pharma Co., Ltd., Osaka (Japan)
Appl. No. 10/48,063 PCT Filed Aug. 07, 2000, PCT No. PCT/JP00/05279 § 371(c)(1), (2), (4) Date Jan. 28, 2002, PCT Pub. No. WO01/10467, PCT Pub. Date Feb. 15, 2001.
Claims priority of application No. 1999/224777 (JP), filed on Aug. 09, 1999.
Int. Cl. A61K 9/22 (2006.01); A61K 9/50 (2006.01)

U.S. Cl. 424—468  [424/490; 424/494; 424/495; 424/497]

6 Claims

1. A sustained release preparation comprising a medicament-containing solid material and a water-insoluble coating film, wherein said medicament-containing solid material consists of a medicament and a pharmaceutical excipient, and said water-insoluble coating film consists essentially of a water-insoluble polymer and a chitosan powder dispersed in said polymer, wherein said polymer is selected from the group consisting of ethyl cellulose, ethyl acrylate-methyl methacrylate-trimethylammoniumethyl methacrylate chloride copolymer, and methyl methacrylate-ethyl acrylate copolymer, said chitosan powder having a mean particle size diameter in the range of about 0.5 μm to about 400 μm, and the weight ratio of said polymer and said chitosan powder is from 4:1 to 1:4.