US 7,601,719 B2
	Compounds, methods and pharmaceutical compositions for inhibiting PARP
Vincent Kalish, Annapolis, Md. (US); Jie Zhang, Ellicott City, Md. (US); Weizheng Xu, Ellicott City, Md. (US); Jia-He Li, Cockeysville, Md. (US); Amy D. Xing, San Diego, Calif. (US); and Qun Liu, Columbia, Md. (US)
Assigned to Eisai Corporation of North America, Woodcliff Lake, N.J. (US)
Filed on Oct. 20, 2008, as Appl. No. 12/254,356.
Application 12/254356 is a division of application No. 11/834334, filed on Aug. 06, 2007, granted, now 7,456,178.
Application 11/834334 is a division of application No. 10/853714, filed on May 26, 2004, granted, now 7,268,138.
Claims priority of provisional application 60/473475, filed on May 28, 2003.
Prior Publication US 2009/0088407 A1, Apr. 02, 2009
Int. Cl. C07D 491/052 (2006.01); A61K 31/5025 (2006.01)

U.S. Cl. 514—250  [544/235; 514/248]

2 Claims

1. A method of treating cancer in a mammal, wherein the cancer is selected from the group consisting of melanoma, lymphoma, and glioblastoma multiforme, comprising administering to the mammal an effective amount of temozolomide and a compound selected from the group consisting of: