US RE40,929 E1
	Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
Joe W. Gray, San Francisco, Calif. (US); Daniel Pinkel, Lafayette, Calif. (US); Olli-Pekka Kallioniemi, Turku (Finland); Anne Kallioniemi, Tampere (Finland); and Masaru Sakamoto, Tokyo (Japan)
Assigned to The Regents of the University of California, Oakland, Calif. (US)
Filed on Mar. 31, 2006, as Appl. No. 11/396,221.
Application 08/478387 is a continuation of application No. 08/312914, filed on Sep. 30, 1994, abandoned.
Application 08/312914 is a continuation of application No. 08/137745, filed on Oct. 19, 1993, abandoned.
Application 08/137745 is a continuation of application No. 08/015390, filed on Feb. 08, 1993, abandoned.
Application 08/015390 is a continuation of application No. 07/670242, filed on Mar. 15, 1991, abandoned.
Application 07/670242 is a continuation in part of application No. 07/659974, filed on Feb. 22, 1991, abandoned.
Application 07/659974 is a continuation in part of application No. 07/537305, filed on Jun. 12, 1990, abandoned.
Application 07/537305 is a continuation in part of application No. 07/497098, filed on Mar. 20, 1990, abandoned.
Application 07/497098 is a continuation in part of application No. 07/444669, filed on Dec. 01, 1989, abandoned.
Application 07/444669 is a continuation in part of application No. 06/937793, filed on Dec. 04, 1986, abandoned.
Application 06/937793 is a continuation in part of application No. 06/819314, filed on Jan. 16, 1986, abandoned.
Application 11/396221 is a reissue of application No. 08/478387, filed on Jun. 07, 1995, now 6,475,720, filed on Nov. 05, 2002.
Int. Cl. C12Q 1/68 (2006.01); C07H 21/00 (2006.01)

U.S. Cl. 435—6  [436/501; 536/23.1; 536/24.3; 536/24.31]

4 Claims

1. A method of staining targeted chromosomal material based upon nucleic acid segment employing a unique sequence high complexity nucleic acid probe of greater than about 50,000 bases, wherein said targeted chromosomal material is a genetic rearrangement associated with chromosome 3 and/or chromosome 17 in humans, said method comprising contacting said chromosomal material with a high complexity nucleic acid probe wherein at least one component of the high complexity nucleic acid probe is targeted to a paracentromeric-specific nucleic acid segment, allowing said probe to bind to said targeted chromosomal material and detecting said bound probe, wherein bound probe is indicative of the presence of target chromosomal material.