US 7,598,293 B2
Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
Bhuniya Debnath, Hyderabad (India); Saibal Kumar Das, Hyderabad (India); Gurram Ranga Madhaven, Hyderabad (India); Javed Iqbal, Hyderabad (India); Ranjan Chakrabarti, Hyderabad (India); and Reeba Kannimel Vikramadithyan, Hyderabad (India)
Assigned to Dr. Reddy's Laboratories, Inc., Upper Saddle River, N.J. (US)
Filed on Feb. 13, 2007, as Appl. No. 11/674,465.
Application 11/674465 is a division of application No. 10/306898, filed on Nov. 27, 2002, granted, now 7,314,889.
Claims priority of application No. 971/MAS/2001 (IN), filed on Dec. 03, 2001.
Prior Publication US 2007/0142470 A1, Jun. 21, 2007
Int. Cl. A61K 31/195 (2006.01); C07C 229/34 (2006.01)
U.S. Cl. 514—562  [562/452] 28 Claims
 
1. A compound of the formula (I)

OG Complex Work Unit Drawing
wherein R1 represents hydrogen, hydroxy, halogen, linear or branched (C1-C12) alkyl, linear or branched (C1-C12) alkoxy, or arylalkyl;
R2 represents hydrogen, halogen, linear or branched (C1-C12) alkyl, linear or branched (C1-C12) alkoxy, (C1-C12) alkanoyl, aryl, arylalkanoyl, or arylalkyl;
R3 represents hydrogen, linear or branched, (C1-C12)alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, (C1-C12)alkanoyl, aroyl, arylalkyl, arylalkanoyl, alkoxyalkyl, alkoxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, or arylaminocarbonyl;
R4 represents hydrogen or linear or branched (C1-C12) alkyl;
Y represents oxygen;
R5 represents hydrogen or alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl;
Ar represents divalent phenylene or diva lent naphthylene;
X represents a bond;
R6 represents hydrogen or group of the structure —OSO2R8 or —NR8SO2R9, R13 represents hydrogen or group of the structure —OSO2R8 or —NR8SO2R9, wherein R8 and R9, which are the same or different, independently represent hydrogen, alkyl, aryl, arylalkyl, alkoxycarbonyl or arylalkoxycarbonyl, with the proviso that R6 is hydrogen only when R13 is not hydrogen and is in the third position of the phenyl ring; and
n is 1 to 6, and m is 0 to 6; and
pharmaceutically acceptable salts of the compound of the formula (I).