US 7,591,948 B2
	Process for production of a regioselective membrane
Michael Müller, Stuttgart (Germany); Christian Oehr, Herrenberg (Germany); Heinrich Malthaner, Stuttgart (Germany); Hermann Goehl, Bisingen-Zimmern (Germany); Reinhold Deppisch, Hechingen (Germany); and Markus Storr, Leinfelden-Echterdingen (Germany)
Assigned to Gambro Lundia AB, Lund (Sweden); and Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V., Munich (Germany)
Appl. No. 10/511,471 PCT Filed Apr. 23, 2003, PCT No. PCT/SE03/00655 § 371(c)(1), (2), (4) Date May 03, 2005, PCT Pub. No. WO03/090910, PCT Pub. Date Nov. 06, 2003.
Claims priority of application No. 0201207 (SE), filed on Apr. 23, 2002.
Prior Publication US 2005/0214162 A1, Sep. 29, 2005
Int. Cl. B01D 61/00 (2006.01); B01D 63/00 (2006.01); B01D 39/14 (2006.01); H05H 1/24 (2006.01)

U.S. Cl. 210—645  [210/500.23; 210/500.37; 210/321.8; 210/321.75; 427/569; 264/48; 435/135]

51 Claims

1. A process for production of a microporous affinity membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said biologically active fluids, comprising subjecting a microporous affinity membrane substrate having a blood side and a filtrate side to one or more cycles of plasma ignition in the presence of a gas mixture comprising at least one modifying gas, wherein the modifying gas comprises an organic precursor with at least one functional group, wherein the at least one functional group comprises an amino, aldehyde, ester, epoxy, hydroxyl, and/or sulfonic acid group, wherein the at least one functional group is regioselectively bound to pore surfaces of the microporous affinity membrane substrate.