| US 7,585,627 B2 | ||
| Polymorphism in tryptophan hydroxylase-2 controls brain serotonin synthesis | ||
| Marc G. Caron, Hillsborough, N.C. (US); Xiaodong Zhang, Durham, N.C. (US); Martin Beaulieu, Durham, N.C. (US); Raul R. Gainetdinov, Chapel Hill, N.C. (US); Tatiana D. Sotnikova, Chapel Hill, N.C. (US); Ranga R. Krishnan, Chapel Hill, N.C. (US); David A. Schwartz, Hillsborough, N.C. (US); Lauranell Burch, Durham, N.C. (US); and Redford B. Williams, Hillsborough, N.C. (US) | ||
| Assigned to Duke University, Durham, N.C. (US) | ||
| Filed on May 20, 2005, as Appl. No. 11/133,949. | ||
| Claims priority of provisional application 60/642869, filed on Jan. 11, 2005. | ||
| Claims priority of provisional application 60/642800, filed on Jan. 11, 2005. | ||
| Claims priority of provisional application 60/629951, filed on Nov. 22, 2004. | ||
| Claims priority of provisional application 60/606811, filed on Sep. 02, 2004. | ||
| Claims priority of provisional application 60/573265, filed on May 21, 2004. | ||
| Prior Publication US 2006/0029951 A1, Feb. 09, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. C12Q 1/68 (2006.01); G01N 33/567 (2006.01); C12P 19/34 (2006.01) | ||
| U.S. Cl. 435—6 [435/7.21; 435/91.2] | 4 Claims |
| 1. A method of screening a human subject comprising:
detecting the presence or absence of a mutation in at least one allele of a Tph2 gene of said human subject;
wherein said mutation encodes a change in an amino acid of the encoded Tph2 protein of SEQ ID NO: 20;
wherein said change in an amino acid is R441H; and
wherein said subject has unipolar major depression.
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