| US 7,572,927 B2 | ||
| Method of producing an o-disubstituted aromatic compound, and method of producing a monosubstituted-monohaloaromatic compound | ||
| Jun-ichi Yoshida, Kyoto (Japan); Aiichiro Nagaki, Kyoto (Japan); and Toshiki Nokami, Kyoto (Japan) | ||
| Assigned to Fujifilm Corporation, Minato-Ku, Tokyo (Japan) | ||
| Filed on Mar. 12, 2007, as Appl. No. 11/716,686. | ||
| Prior Publication US 2008/0194816 A1, Aug. 14, 2008 | ||
| Int. Cl. C07F 7/00 (2006.01); C07F 7/04 (2006.01); C07C 27/00 (2006.01) | ||
| U.S. Cl. 556—95 [556/478; 568/878; 568/893] | 6 Claims |
| 1. A method of producing an o-disubstituted aromatic compound, comprising: continuously conducting at least the following
steps:
(a) a step of mono-lithiating one halogen atom of an o-dihaloaromatic compound, using a first microreactor;
(b) a step of making the thus-obtained monolithiated product to react with an electrophilic compound, using a second microreactor,
to obtain a monosubstituted-monohaloaromatic compound;
(c) a step of lithiating the other halogen atom of the o-dihaloaromatic compound, using a third microreactor; and
(d) a step of making the thus-obtained lithiated product successively to react with an electrophilic compound, using a fourth
microreactor,
wherein a reaction temperature in a flow channel of each of the first microreactor and the second microreactor is in the range
of from −85° C. to −60° C.
|