| US 7,572,815 B2 | ||
| Amide derivative | ||
| Tadakiyo Nakagawa, Kawasaki (Japan); Tamotsu Suzuki, Kawasaki (Japan); Kaoru Takenaka, Kawasaki (Japan); Shinichi Fujita, Kawasaki (Japan); Youji Yamada, Kawasaki (Japan); Yoichiro Shima, Kawasaki (Japan); Tatsuya Okuzumi, Kawasaki (Japan); Toshihiko Yoshimura, Kawasaki (Japan); Masanao Yoshida, Kawasaki (Japan); and Masahiro Murata, Kawasaki (Japan) | ||
| Assigned to Ajinomoto Co., Inc., Tokyo (Japan) | ||
| Filed on Nov. 18, 2005, as Appl. No. 11/281,627. | ||
| Application 11/281627 is a continuation of application No. PCT/JP2004/007221, filed on May 20, 2004. | ||
| Claims priority of application No. 2003-142681 (JP), filed on May 20, 2003. | ||
| Prior Publication US 2006/0128755 A1, Jun. 15, 2006 | ||
| Int. Cl. C07D 401/04 (2006.01); A61K 31/444 (2006.01) | ||
| U.S. Cl. 514—332 [514/318; 514/330; 546/193; 546/225] | 12 Claims |
1. An amide compound represented by the formula (X):
 A is any of an aryl group, a heteroaryl group, and a cycloalkyl group;
X is a nitrogen atom or CR17;
Y is —NH— or —NH—CH2—;
R8 is an alkyl group optionally having one or more substituents, a halogen atom, a nitro group, or a cyano group; and
R12, R13, R14, R15, R16, and R17 may be the same or different and each is a hydrogen atom, a halogen atom, a cyano group,
a nitro group, an alkyl group optionally having one or more substituents, an alkenyl group optionally having one or more substituents,
or —ZR18, wherein:
Z is —NR19-, —NHC(═O)—, —O—, —C(═O)—, —NH—, —NHS(O)2—, —C(═O)O—, or —S—; and
R18 and R19 may be the same or different and each is a hydrogen atom, an alkyl group optionally having one or more substituents,
or an aryl group optionally having one or more substituents,
a pharmaceutically acceptable salt thereof, or a hydrate thereof.
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