| US 7,572,576 B2 | ||
| Method of predicting genetic risk for hypertension | ||
| Yoshiji Yamada, Nagoya (Japan); and Mitsuhiro Yokota, Nagoya (Japan) | ||
| Assigned to Nagoya Industrial Science Research Institute, Nagoya-shi (Japan) | ||
| Appl. No. 10/528,659 PCT Filed Sep. 22, 2003, PCT No. PCT/JP03/12052 § 371(c)(1), (2), (4) Date Oct. 05, 2005, PCT Pub. No. WO2004/029243, PCT Pub. Date Apr. 08, 2004. |
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| Claims priority of application No. 2002-280034 (JP), filed on Sep. 25, 2002. | ||
| Prior Publication US 2006/0099594 A1, May 11, 2006 | ||
| Int. Cl. C12Q 1/68 (2006.01); C07H 21/04 (2006.01) | ||
| U.S. Cl. 435—6 [536/23.5] | 1 Claim |
| 1. A method for assessing the genetic risk for hypertension in a human male subject, the method comprising the following steps
(i) to (iii):
(i) analyzing the following polymorphisms (1) to (3) in a nucleic acid sample from the human male subject:
(1) a polymorphism at the base number position 1648 of the glycoprotein Ia (Gpla) gene, wherein the polymorphism is A1648G;
(2) a polymorphism at the base number position 190 of the chemokine receptor 2 (CCR2) gene, wherein the polymorphism is G190A;
and
(3) a polymorphism at the base number position 1100 of the apolipoprotein C-III (apo CIII) gene, wherein the polymorphism
is C1100T;
(ii) determining, based on the information about polymorphisms which was obtained in the step (i), the genotype of the nucleic
acid sample from the human male subject; and
(iii) assessing, based on the genotype determined, a genetic risk for hypertension in the human male subject, wherein a genotype
including A at position 1648 of the Gpla gene, A at position 190 of the CCR2 gene, and C at position 1100 of the apo CIII
gene indicates a genetic risk for hypertension in the human male subject.
|