| US 7,563,350 B2 | ||
| Small volume in vitro analyte sensor | ||
| Benjamin J. Feldman, Oakland, Calif. (US); Adam Heller, Austin, Tex. (US); Ephraim Heller, Oakland, Calif. (US); Fei Mao, Fremont, Calif. (US); Joseph A. Vivolo, San Francisco, Calif. (US); Jeffery V. Funderburk, Fremont, Calif. (US); Fredric C. Colman, Oakland, Calif. (US); and Rajesh Krishnan, Fremont, Calif. (US) | ||
| Assigned to Abbott Diabetes Care Inc., Alameda, Calif. (US) | ||
| Filed on Sep. 15, 2003, as Appl. No. 10/663,153. | ||
| Application 10/663153 is a continuation of application No. 09/594285, filed on Jun. 15, 2000, granted, now 6,618,934. | ||
| Application 09/594285 is a continuation of application No. 09/295962, filed on Apr. 21, 1999, granted, now 6,338,790. | ||
| Claims priority of provisional application 60/103627, filed on Oct. 08, 1998. | ||
| Claims priority of provisional application 60/105773, filed on Oct. 08, 1998. | ||
| Prior Publication US 2004/0054267 A1, Mar. 18, 2004 | ||
| Int. Cl. G01N 27/327 (2006.01) | ||
| U.S. Cl. 204—403.04 [204/403.11; 204/403.13; 204/403.14] | 17 Claims |
| 1. A sensor strip for determining the concentration of an analyte in a sample, the sensor strip comprising:
(a) a first substrate having a proximal end and an opposite distal end and a length therebetween, the distal end being configured
and arranged for insertion into a sensor reader, the first substrate defining a first side edge and a second side edge of
the sensor extending from the proximal end to the distal end of the first substrate, the first side edge and the second side
edge defining a width of the first substrate and of the sensor;
(b) a second substrate positioned over the first substrate;
(c) at least one working electrode comprising gold on the first substrate;
(d) at least one counter electrode comprising gold on the first substrate, with a portion of the counter electrode located
25-1000 micrometers from a portion of the at least one working electrode;
(e) a spacer between the first and second substrates, the spacer layer having a length less than the length of the first substrate
and a width the same as the width of the first substrate, the spacer layer defining:
(i) a first aperture along the proximal end of the sensor, and
(ii) a sample chamber extending from the first aperture to a second aperture, the sample chamber having a volume of no more
than 1 microliter, and the sample chamber defining a recess having therein at least a portion of the working electrode and
a redox mediator; and
(f) the second aperture forming a rectangular vent hole through the second substrate.
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