	US 7,563,255 B2
	Implantable drug delivery device and use thereof
Anthony P. Adamis, Jamaica Plain, Mass. (US); Joan W. Miller, Winchester, Mass. (US); Evangelos S. Gragoudas, Lexington, Mass. (US); Mark J. Mescher, West Newton, Mass. (US); Christopher E. Dubé, Lexington, Mass. (US); Jeffrey T. Borenstein, Hilliston, Mass. (US); Marcie G. Weinstein, Pittsburgh, Pa. (US); Raanan A. Miller, Chestnut Hill, Mass. (US); and Mitchell L. Hansberry, Southborough, Mass. (US)
Assigned to Massachusetts Eye and Ear Infirmary, Boston, Mass. (US); and The Charles Stark Draper Laboratory Inc., Cambridge, Mass. (US)
Filed on May 02, 2002, as Appl. No. 10/139,656.
Claims priority of provisional application 60/288373, filed on May 03, 2001.
Claims priority of provisional application 60/291340, filed on May 16, 2001.
Claims priority of provisional application 60/291445, filed on May 16, 2001.
Claims priority of provisional application 60/332199, filed on Nov. 21, 2001.
Claims priority of provisional application 60/332200, filed on Nov. 21, 2001.
Claims priority of provisional application 60/334177, filed on Nov. 29, 2001.
Prior Publication US 2003/0069560 A1, Apr. 10, 2003
Int. Cl. A61M 35/00 (2006.01)

U.S. Cl. 604—294 [604/89; 604/132; 604/891.1]

63 Claims

1. An implantable drug delivery device, comprising:

(a) a casing defining an inner volume, and comprising an outer surface, the outer surface comprising an eye-contacting surface, wherein the eye-contacting surface comprises a shape complementary to an outer surface of a mammalian eye, and wherein when implanted, the eye-contacting surface substantially conforms to the outer surface of a mammalian eye, the eye-contacting surface defining an aperture port passing therethrough, wherein the inner volume is in fluid flow communication with the outside of the casing;

(b) a reservoir member comprising a drum disposed within the casing, wherein the reservoir member defines a cavity for receiving the drug; and

(c) a seal attached to the reservoir member for sealing drug within the cavity, which when punctured permits drug disposed within the cavity to be released into the inner volume and to exit the casing via the aperture port defined in the eye-contacting surface.