US 7,399,586 B2
	Modulation of biological signal transduction by RNA interference
Richard Klinghoffer, Seattle, Wash. (US); and Stephen Patrick Lewis, Mountlake Terrace, Wash. (US)
Assigned to Ceptyr, Inc., Redmond, Wash. (US)
Filed on May 23, 2003, as Appl. No. 10/444,795.
Claims priority of provisional application 60/462942, filed on Apr. 14, 2003.
Claims priority of provisional application 60/383249, filed on May 23, 2002.
Prior Publication US 2004/0077574 A1, Apr. 22, 2004
Int. Cl. C12Q 1/68 (2006.01); C12P 19/34 (2006.01); C12N 15/03 (2006.01); C12N 15/00 (2006.01); C07N 21/04 (2006.01)

U.S. Cl. 435—6  [435/91.1; 435/91.31; 435/320.7; 435/375; 435/455; 536/23.1; 536/24.5]

22 Claims

1. An isolated small interfering RNA (siRNA) polynucleotide, comprising at least one polynucleotide that is selected from the group consisting of (i) a polynucleotide comprising the nucleotide sequence set forth in SEQ ID NO:445, (ii) a polynucleotide comprising the nucleotide sequence set forth in SEQ ID NO:446, (iii) a polynucleotide comprising the nucleotide sequence set forth in SEQ ID NO:447 and (iv) a polynucleotide comprising the nucleotide sequence set forth in SEQ ID NO:448.