| US 7,547,433 B2 | ||
| Liquid formulations for the prevention and treatment of mucosal diseases and disorders | ||
| Jeremy E. Jacob, Lewisville, Tex. (US); David P. Nowotnik, Colleyville, Tex. (US); and Christiane M. Baud, Dallas, Tex. (US) | ||
| Assigned to Access Pharmaceuticals, Inc., Dallas, Tex. (US) | ||
| Filed on Feb. 15, 2002, as Appl. No. 10/77,459. | ||
| Claims priority of provisional application 60/269049, filed on Feb. 15, 2001. | ||
| Prior Publication US 2002/0168334 A1, Nov. 14, 2002 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 8/00 (2006.01); A61K 8/18 (2006.01); A61K 47/32 (2006.01); A61Q 11/00 (2006.01) | ||
| U.S. Cl. 424—49 [424/401; 424/78.18; 424/78.24; 424/78.29; 424/78.31; 424/78.35; 514/772.1; 514/772.5; 514/772.7; 514/780; 514/781; 514/782; 514/901] | 18 Claims |
| 1. A pseudoplastic liquid composition for treating or inhibiting an oral mucocutaneous disorder, said liquid composition having
a zero shear viscosity at 37±1 degrees Celsius of 100-20,000 centipoise, comprising 0.1 to 3.0 wt/wt % of one or more mucoadhesives
in an aqueous solution, wherein the mucoadhesive(s) is/are one or more linear or cross-linked polymer(s) selected from the
group consisting of polyacrylic acid, carbopol, carboxymethylcellulose, hydroxyalkylcellulose, dextran sulfate, chitosan,
and a water-soluble vinyl polymer; wherein said liquid composition, when administered to an oral mucosa:
1) remains liquid when shear is applied due to swishing the liquid in the mouth; and
2) attaches to and coats the oral mucosa upon discontinuance of said shear.
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