| US 7,528,127 B2 | ||
| Short-acting benzodiazepines | ||
| Paul L. Feldman, Research Triangle Park, N.C. (US); David Kendall Jung, Research Triangle Park, N.C. (US); Istvan Kaldor, Research Triangle Park, N.C. (US); Gregory J. Pacofsky, Research Triangle Park, N.C. (US); Jeffrey A. Stafford, Research Triangle Park, N.C. (US); and Jeffrey H. Tidwell, Research Triangle Park, N.C. (US) | ||
| Assigned to CeNes Limited, Cambridge (United Kingdom) | ||
| Filed on Jan. 05, 2007, as Appl. No. 11/650,636. | ||
| Application 11/650636 is a division of application No. 09/980680, granted, now 7,160,880, previously published as PCT/US00/13134, filed on May 12, 2000. | ||
| Claims priority of application No. 9911152.8 (GB), filed on May 14, 1999. | ||
| Prior Publication US 2007/0135420 A1, Jun. 14, 2007 | ||
| Int. Cl. A61P 25/20 (2006.01); A61K 31/5517 (2006.01); C07D 487/02 (2006.01) | ||
| U.S. Cl. 514—220 [540/561] | 10 Claims |
1. A compound of formula (I):
 W is H, a C1-C4 branched alkyl, or straight chained alkyl;
X is CH2, NH or NCH3; n is 1 or 2;
Y is O or CH2; m is 0 or 1, provided that if X is CH2, n is 1 and m is 0, then R1 is not CH2CH3;
R1 is H, a C1-C7 straight chain alkyl, a C3-C7 branched chain alkyl, a C1-4haloalkyl, a C3-C7 cycloalkyl, an aryl, a heteroaryl, an aralkyl, or a heteroaralkyl;
R2 is phenyl, 2-halophenyl or 2-pyridyl,
R3 is H, Cl, Br, F, I, CF3 or NO2;
R8 is hydrogen, C1-4alkyl or C1-3hydroxyalkyl;
U is CR9 where R9 is H, C1-3hydroxyalkyl, C1-4alkoxy, or C1-4alkyl;
and V is CH; or a pharmaceutically acceptable salt or solvate thereof.
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