| US 7,517,658 B2 | ||
| Methods for preparing compositions using a SNORF33 receptor | ||
| Beth E. Borowsky, Flemington, N.J. (US); Kristine L. Ogozalek, Rochelle Park, N.J. (US); and Kenneth A. Jones, Glen Rock, N.J. (US) | ||
| Assigned to H. Lundbeck A/S, Valby-Copenhagen (Denmark) | ||
| Filed on Sep. 15, 2005, as Appl. No. 11/227,855. | ||
| Application 11/227855 is a continuation of application No. 09/980145, granted, now 6,987,005, filed on Jan. 17, 2006, previously published as PCT/US00/14654, filed on May 26, 2000. | ||
| Application 09/980145 is a continuation in part of application No. 09/413433, filed on Oct. 06, 1999, abandoned. | ||
| Application 09/413433 is a continuation in part of application No. 09/322257, filed on May 28, 1999, abandoned. | ||
| Prior Publication US 2007/0028315 A1, Feb. 01, 2007 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. G01N 33/567 (2006.01); G01N 33/53 (2006.01); C07K 14/47 (2006.01) | ||
| U.S. Cl. 435—7.1 [435/7.2; 435/7.21; 436/501; 530/350; 536/23.5] | 8 Claims |
| 1. A method for preparing a composition which comprises:
(a) determining whether a chemical compound is a human SNORF33 receptor agonist which comprises contacting cells transfected
with and expressing DNA encoding the human SNORF33 receptor, wherein the cells prior to being transfected with the DNA do
not express the human SNORF33 receptor, with the compound under conditions permitting the activation of the human SNORF33
receptor, and detecting any increase in human SNORF33 receptor activation, so as to thereby determine whether the compound
is a human SNORF33 receptor agonist;
(b) recovering the compound free of any human SNORF33 receptor; and
(c) admixing the compound with a pharmaceutically acceptable carrier;
wherein the human SNORF33 receptor has the amino acid sequence identical to that shown in SEQ ID NO: 6 or that encoded by
plasmid pcDNA3.1-hSNORF33-f (ATCC Patent Deposit Designation PTA-398) or plasmid pEXJ-hSNORF33-f (ATCC Patent Deposit Designation
PTA-570).
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