	US 7,488,824 B2
	Process for the production of substituted nicotinic acid esters
David Anthony Jackson, Muenchwilen (Switzerland); and Martin Charles Bowden, West Yorkshire (United Kingdom)
Assigned to Syngenta Crop Protection, Inc., Greensboro, N.C. (US)
Appl. No. 10/547,840 PCT Filed Mar. 05, 2004, PCT No. PCT/EP2004/002291 § 371(c)(1), (2), (4) Date Sep. 06, 2005, PCT Pub. No. WO2004/078729, PCT Pub. Date Sep. 16, 2004.
Claims priority of application No. 373/03 (CH), filed on Mar. 07, 2003.
Prior Publication US 2006/0199964 A1, Sep. 07, 2006
Int. Cl. C07D 401/00 (2006.01); C07D 417/00 (2006.01); C07D 211/70 (2006.01); C07D 405/00 (2006.01); C07D 411/00 (2006.01); C07D 413/00 (2006.01); C07C 69/73 (2006.01)

U.S. Cl. 544—333 [546/268.7; 546/315; 546/282.4; 546/280.4; 546/276.1; 546/268.1; 546/272.1; 546/284.4; 546/282.1; 560/183]

3 Claims

1. A process for the preparation of a compound of formula I

wherein

R is methyl or ethyl;

R₀₅is Hydrogen;

R₁is —CH₂—, —CH₂CH₂—, —CH₂CH₂CH₂—, —CF₂—, —CH═CHCH₂—, —CH(CH₃)— or —C≡CCH₂—;

R₄is trifluoromethyl, chlorodifluoromethyl or difluoromethyl;

X₁is oxygen;

R₂is CH₃, CH₂CH₃, CH₂OCH₃, CH₂OCH₂CH₃, CH₂CH₂OCH₃, CH₂CH₂OCH₂CH₃, CH₂CF₃, propargyl, cyclopropylmethyl, benzyl, CH₂CH₂SO₂CH₃or CH₂CH₂OCH₂CH₂OCH₃;

which process

comprises reacting

a compound of formula II

wherein R₃is C₁-C₈alkyl or C₃-C₆cycloalkyl and R₄and R₀₅are as defined for formula I, with a compound of formula III

wherein R, R₁, R₂and X₁are as defined for formula I, in an inert solvent in the presence of a proton source.