| US 7,482,373 B2 | ||
| Bis-benzimidazoles and related compounds as potassium channel modulators | ||
| Xiaodong Wang, Chapel Hill, N.C. (US); Alan Bradley Fulp, Willow Springs, N.C. (US); Albert Michiel van Rhee, Durham, N.C. (US); and Kerry Leigh Spear, Raleigh, N.C. (US) | ||
| Assigned to Icagen, Inc., Durham, N.C. (US) | ||
| Filed on Sep. 29, 2006, as Appl. No. 11/540,772. | ||
| Application 11/540772 is a division of application No. 10/437732, filed on May 13, 2003, granted, now 7,132,439. | ||
| Claims priority of provisional application 60/380367, filed on May 13, 2002. | ||
| Prior Publication US 2007/0027200 A1, Feb. 01, 2007 | ||
| Int. Cl. A61K 31/4184 (2006.01); C07D 235/04 (2006.01); C07D 235/20 (2006.01) | ||
| U.S. Cl. 514—394 [548/305.4] | 21 Claims |
1. A method of decreasing ion flow through Ca2+ activated small conductance potassium (SK) channels in a cell, said method comprising contacting said cell with a SK channel-modulating
amount of a compound of the formula:
 in which
A, D and E are independently selected from substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl
ring systems;
X1 and X2 independently represent NR1, S, O, NHC(R2), SC(R3), OC(R4), and C(R5); and
R1, R2, R3, R4, and R5 are members independently selected from the group consisting of H and substituted or unsubstituted alkyl, substituted or unsubstituted
arylalkyl and substituted or unsubstituted heteroaryl.
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