| US 7,481,212 B2 | ||
| Increased dosage metered dose inhaler | ||
| Carlos Schuler, Cupertino, Calif. (US); Andrew R. Clark, Woodside, Calif. (US); Kevin R. Walsh, San Francisco, Calif. (US); and William Alston, San Jose, Calif. (US) | ||
| Assigned to Nektar Therapeutics, San Carlos, Calif. (US) | ||
| Filed on Oct. 30, 2003, as Appl. No. 10/698,025. | ||
| Claims priority of provisional application 60/422563, filed on Oct. 30, 2002. | ||
| Prior Publication US 2005/0051162 A1, Mar. 10, 2005 | ||
| Int. Cl. A61M 11/00 (2006.01) | ||
| U.S. Cl. 128—200.23 [128/200.14] | 32 Claims |
| 1. An aerosolization apparatus comprising:
a container containing a pharmaceutical formulation, the pharmaceutical formulation comprising an active agent, the container
further containing a first pressurizer comprising a fluid propellant;
a metering chamber in communication with the container, the metering chamber adapted to hold a metered amount of the pharmaceutical
formulation;
a valve to allow the metered amount of the pharmaceutical formulation to be released from the metering chamber when the valve
is actuated; and
a second pressurizer that applies pressure to the pharmaceutical formulation in the metering chamber while the pharmaceutical
formulation is being released from the metering chamber,
wherein the first and second pressurizers independently supply pressure to the pharmaceutical formulation, and
wherein the metering chamber is sized so that at least 2 mg of the active agent is aerosolized for delivery to a user during
inhalation.
|