| US 7,473,692 B2 | ||
| Sulfonamide derivatives as D3-receptor ligands | ||
| János Galambos, Budapest (Hungary); Katalin Nógrádi, Budapest (Hungary); Éva Ágainé Csongor, Budapest (Hungary); György Miklós Keserü, Telki (Hungary); István Vágó, Budapest (Hungary); György Domány, Obánya (Hungary); Béla Kiss, Budapest (Hungary); István Gyertyán, Budapest (Hungary); István Laszlovszky, Budapest (Hungary); and Judit Laszy, Nagykovácsi (Hungary) | ||
| Assigned to Richter Gedeon Vegyeszeti Gyar Rt., Budapest (Hungary) | ||
| Appl. No. 10/491,150 PCT Filed Sep. 25, 2002, PCT No. PCT/HU02/00093 § 371(c)(1), (2), (4) Date Oct. 22, 2004, PCT Pub. No. WO03/029233, PCT Pub. Date Apr. 10, 2003. |
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| Claims priority of application No. 103988 (HU), filed on Sep. 28, 2001. | ||
| Prior Publication US 2005/0107397 A1, May 19, 2005 | ||
| Int. Cl. A61K 31/4965 (2006.01); A01N 43/40 (2006.01); C07D 401/00 (2006.01); C07D 295/00 (2006.01); C07D 241/04 (2006.01); C07D 211/00 (2006.01); C07D 211/54 (2006.01); C07D 211/40 (2006.01); C07D 211/56 (2006.01); C07D 211/92 (2006.01); C07D 211/18 (2006.01) | ||
| U.S. Cl. 514—255.03 [514/327; 514/329; 544/363; 544/379; 544/360; 544/392; 546/216; 546/217; 546/223; 546/232] | 22 Claims |
1. A compound of formula (I)
![]() or a salt thereof,
wherein
X represents a nitrogen atom or CH group;
Y represents a bond when X stands for nitrogen, or an oxygen atom or NH or CH2 or OCH2 group when X stands for CH group;
R1, R2, and R3 may be the same or different and represent independently a substituent selected from hydrogen, halogen, C1-6-alkyl, C1-6 alkoxy, cyano, hydroxy, trifluoromethyl, C1-6-alkylsulfonyloxy, trifluoromethanesulfonyloxy, C1-6-alkanoyloxy, amino, alkylamino, alkanoylamino, alkylsulfonylamino, arylsulfonylamino, aminocarbonyl, carboxy, N-hydroxycarmamimidoyl,
carbamimidoyl, hydroxycarbamoyl, thiocarbamoyl, sulfamoyl, mono or bicyclic heterocyclic group or optionally substituted phenyl,
or two adjacent groups of R1, R2, and R3 may combine to form an optionally substituted fused mono or bicyclic heterocyclic group; and
Q represents a dialkylamino group or an optionally substituted alkyl, aryl, heteroaryl, aralkyl or heteroaralkyl group
wherein “optionally substituted” means, independently at each use, optionally substituted with one or more substituents selected
from the group consisting of halogen, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, C1-6-alkanoyl, methylenedioxy, C1-6-alkylamino, C1-6-alkanoylamino, optionally substituted aroyl, aryloxy, aminosulfonyl, arylsulfonylamido, optionally substituted mono or bicyclic
aromatic ring, and optionally substituted heteroaromatic ring.
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